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Title | Discovery of a Novel, First-in-Class, Orally Bioavailable Azaindole Inhibitor (VX-787) of Influenza PB2. |
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Journal, issue, pages | J. Med. Chem., Vol. 57, Page 6668-6678, Year 2014 |
Publish date | Oct 24, 2013 (structure data deposition date) |
Authors | Clark, M.P. / Ledeboer, M.W. / Davies, I. / Byrn, R.A. / Jones, S.M. / Perola, E. / Tsai, A. / Jacobs, M. / Nti-Addae, K. / Bandarage, U.K. ...Clark, M.P. / Ledeboer, M.W. / Davies, I. / Byrn, R.A. / Jones, S.M. / Perola, E. / Tsai, A. / Jacobs, M. / Nti-Addae, K. / Bandarage, U.K. / Boyd, M.J. / Bethiel, R.S. / Court, J.J. / Deng, H. / Duffy, J.P. / Dorsch, W.A. / Farmer, L.J. / Gao, H. / Gu, W. / Jackson, K. / Jacobs, D.H. / Kennedy, J.M. / Ledford, B. / Liang, J. / Maltais, F. / Murcko, M. / Wang, T. / Wannamaker, M.W. / Bennett, H.B. / Leeman, J.R. / McNeil, C. / Taylor, W.P. / Memmott, C. / Jiang, M. / Rijnbrand, R. / Bral, C. / Germann, U. / Nezami, A. / Zhang, Y. / Salituro, F.G. / Bennani, Y.L. / Charifson, P.S. |
External links | J. Med. Chem. / PubMed:25019388 |
Methods | X-ray diffraction |
Resolution | 2.3 - 2.82 Å |
Structure data | PDB-4nce: PDB-4ncm: PDB-4p1u: |
Chemicals | ChemComp-MGT: ChemComp-11H: ChemComp-HOH: ChemComp-704: ChemComp-21G: |
Source |
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Keywords | TRANSCRIPTION/TRANSCRIPTION INHIBITOR / influenza virus / cap-binding domain / TRANSCRIPTION-TRANSCRIPTION INHIBITOR complex / RNA-dependent RNA polymerase / transcription / PB2 subunit / transferase/transferase inhibitor / small-molecule drug / inhibitor / flu / m7-GTP pocket / transferase-transferase inhibitor complex |