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Structure paper

TitleCovalent agonists for studying G protein-coupled receptor activation.
Journal, issue, pagesProc. Natl. Acad. Sci. USA, Vol. 111, Page 10744-10748, Year 2014
Publish dateJun 10, 2014 (structure data deposition date)
AuthorsWeichert, D. / Kruse, A.C. / Manglik, A. / Hiller, C. / Zhang, C. / Hubner, H. / Kobilka, B.K. / Gmeiner, P.
External linksProc. Natl. Acad. Sci. USA / PubMed:25006259
MethodsX-ray diffraction
Resolution3.3 Å
Structure data

PDB-4qkx:
Structure of beta2 adrenoceptor bound to a covalent agonist and an engineered nanobody
Method: X-RAY DIFFRACTION / Resolution: 3.3 Å

Chemicals

ChemComp-NA:
Unknown entry

ChemComp-35V:
4-[(1R)-1-hydroxy-2-({2-[3-methoxy-4-(2-sulfanylethoxy)phenyl]ethyl}amino)ethyl]benzene-1,2-diol

Source
  • enterobacteria phage t4 (virus)
  • homo sapiens (human)
  • lama glama (llama)
KeywordsMEMBRANE PROTEIN/IMMUNE SYSTEM / 7-transmembrane helices / Signal transduction / G proteins / Membrane / MEMBRANE PROTEIN-IMMUNE SYSTEM complex

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