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Structure paper

TitleSmall molecule disruptors of the glucokinase-glucokinase regulatory protein interaction: 4. Exploration of a novel binding pocket.
Journal, issue, pagesJ. Med. Chem., Vol. 57, Page 5949-5964, Year 2014
Publish dateJan 23, 2014 (structure data deposition date)
AuthorsHong, F.T. / Norman, M.H. / Ashton, K.S. / Bartberger, M.D. / Chen, J. / Chmait, S. / Cupples, R. / Fotsch, C. / Jordan, S.R. / Lloyd, D.J. ...Hong, F.T. / Norman, M.H. / Ashton, K.S. / Bartberger, M.D. / Chen, J. / Chmait, S. / Cupples, R. / Fotsch, C. / Jordan, S.R. / Lloyd, D.J. / Sivits, G. / Tadesse, S. / Hale, C. / St Jean, D.J.
External linksJ. Med. Chem. / PubMed:25001129
MethodsX-ray diffraction
Resolution2.4 Å
Structure data

PDB-4olh:
Human GKRP Bound to AMG5106 and Sorbitol-6-Phosphate
Method: X-RAY DIFFRACTION / Resolution: 2.4 Å

Chemicals

ChemComp-2TO:
2-(2-{4-[(6-aminopyridin-3-yl)sulfonyl]piperazin-1-yl}-3,3'-bipyridin-5-yl)-1,1,1,3,3,3-hexafluoropropan-2-ol

ChemComp-S6P:
D-SORBITOL-6-PHOSPHATE

ChemComp-IOD:
IODIDE ION

ChemComp-GOL:
GLYCEROL

ChemComp-SO4:
SULFATE ION

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsCARBOHYDRATE BINDING PROTEIN / SIS domain / Regulatory Protein / binds to and inhibits Glucokinase / Glucokinase / Liver

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