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-Structure paper
Title | Discovery of potent and selective spiroindolinone MDM2 inhibitor, RO8994, for cancer therapy. |
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Journal, issue, pages | Bioorg. Med. Chem., Vol. 22, Page 4001-4009, Year 2014 |
Publish date | Jul 28, 2013 (structure data deposition date) |
Authors | Zhang, Z. / Ding, Q. / Liu, J.J. / Zhang, J. / Jiang, N. / Chu, X.J. / Bartkovitz, D. / Luk, K.C. / Janson, C. / Tovar, C. ...Zhang, Z. / Ding, Q. / Liu, J.J. / Zhang, J. / Jiang, N. / Chu, X.J. / Bartkovitz, D. / Luk, K.C. / Janson, C. / Tovar, C. / Filipovic, Z.M. / Higgins, B. / Glenn, K. / Packman, K. / Vassilev, L.T. / Graves, B. |
External links | Bioorg. Med. Chem. / PubMed:24997575 |
Methods | X-ray diffraction |
Resolution | 1.14 - 1.6 Å |
Structure data | PDB-4lwt: PDB-4lwu: |
Chemicals | ChemComp-20Q: ChemComp-SO4: ChemComp-HOH: ChemComp-20U: |
Source |
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Keywords | Ligase/Ligase Inhibitor / MDM2 / Indolinone / E3 Ubiquitin Ligase / p53 / Nucleus / Ligase-Ligase Inhibitor complex / Spiroindolinone |