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TitleNeutralizing antibodies to HIV-1 envelope protect more effectively in vivo than those to the CD4 receptor.
Journal, issue, pagesSci Transl Med, Vol. 6, Page 243ra88-243ra88, Year 2014
Publish dateApr 22, 2014 (structure data deposition date)
AuthorsPegu, A. / Yang, Z.Y. / Boyington, J.C. / Wu, L. / Ko, S.Y. / Schmidt, S.D. / McKee, K. / Kong, W.P. / Shi, W. / Chen, X. ...Pegu, A. / Yang, Z.Y. / Boyington, J.C. / Wu, L. / Ko, S.Y. / Schmidt, S.D. / McKee, K. / Kong, W.P. / Shi, W. / Chen, X. / Todd, J.P. / Letvin, N.L. / Huang, J. / Nason, M.C. / Hoxie, J.A. / Kwong, P.D. / Connors, M. / Rao, S.S. / Mascola, J.R. / Nabel, G.J.
External linksSci Transl Med / PubMed:24990883
MethodsX-ray diffraction
Resolution3.65 Å
Structure data

PDB-4q6i:
Crystal structure of murine 2D5 Fab, a potent anti-CD4 HIV-1-neutralizing antibody in complex with CD4
Method: X-RAY DIFFRACTION / Resolution: 3.65 Å

Source
  • homo sapiens (human)
  • mus musculus (house mouse)
KeywordsIMMUNE SYSTEM / Ig fold / Antibody / anti-CD4 / HIV-1 neutralization / CD4

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