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TitleStructure, biochemistry, and inhibition of essential 4'-phosphopantetheinyl transferases from two species of mycobacteria.
Journal, issue, pagesAcs Chem. Biol., Vol. 9, Page 1939-1944, Year 2014
Publish dateJun 4, 2014 (structure data deposition date)
AuthorsVickery, C.R. / Kosa, N.M. / Casavant, E.P. / Duan, S. / Noel, J.P. / Burkart, M.D.
External linksAcs Chem. Biol. / PubMed:24963544
MethodsX-ray diffraction
Resolution1.59 - 1.65 Å
Structure data

PDB-4qjk:
Crystal structure of M. tuberculosis phosphopantetheinyl transferase PptT
Method: X-RAY DIFFRACTION / Resolution: 1.59 Å

PDB-4qjl:
Crystal structure of M. ulcerans phosphopantetheinyl transferase MuPPT
Method: X-RAY DIFFRACTION / Resolution: 1.65 Å

Chemicals

ChemComp-COA:
COENZYME A

ChemComp-SO4:
SULFATE ION

ChemComp-HOH:
WATER

ChemComp-MG:
Unknown entry

Source
  • mycobacterium tuberculosis (bacteria)
  • mycobacterium ulcerans (bacteria)
KeywordsTRANSFERASE / Phosphopantetheinyl Transferase / CoA Binding

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