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Structure paper

Title3-Hydroxyquinolin-2(1H)-ones As Inhibitors of Influenza A Endonuclease.
Journal, issue, pagesACS Med Chem Lett, Vol. 4, Page 547-550, Year 2013
Publish dateMay 2, 2013 (structure data deposition date)
AuthorsSagong, H.Y. / Parhi, A. / Bauman, J.D. / Patel, D. / Vijayan, R.S. / Das, K. / Arnold, E. / LaVoie, E.J.
External linksACS Med Chem Lett / PubMed:24936242
MethodsX-ray diffraction
Resolution1.75 Å
Structure data

PDB-4kil:
7-(4-fluorophenyl)-3-hydroxyquinolin-2(1H)-one bound to influenza 2009 H1N1 endonuclease
Method: X-RAY DIFFRACTION / Resolution: 1.75 Å

Chemicals

ChemComp-MN:
Unknown entry

ChemComp-SO4:
SULFATE ION

ChemComp-EDO:
1,2-ETHANEDIOL

ChemComp-1R5:
7-(4-fluorophenyl)-3-hydroxyquinolin-2(1H)-one

ChemComp-HOH:
WATER

Source
  • influenza a virus (a/lima/wrair1695p/2009(h1n1))
KeywordsRna binding protein/inhibitor / endonuclease / cap-snatching / influenza / Rna binding protein-inhibitor complex

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