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Structure paper

TitleMolecular basis of gain-of-function LEOPARD syndrome-associated SHP2 mutations.
Journal, issue, pagesBiochemistry, Vol. 53, Page 4136-4151, Year 2014
Publish dateJan 17, 2014 (structure data deposition date)
AuthorsYu, Z.H. / Zhang, R.Y. / Walls, C.D. / Chen, L. / Zhang, S. / Wu, L. / Liu, S. / Zhang, Z.Y.
External linksBiochemistry / PubMed:24935154
MethodsX-ray diffraction
Resolution2.2 - 2.7 Å
Structure data

PDB-4ohd:
LEOPARD Syndrome-Associated SHP2/A461T mutant
Method: X-RAY DIFFRACTION / Resolution: 2.7 Å

PDB-4ohe:
LEOPARD Syndrome-Associated SHP2/G464A mutant
Method: X-RAY DIFFRACTION / Resolution: 2.506 Å

PDB-4ohh:
LEOPARD Syndrome-Associated SHP2/Q506P mutant
Method: X-RAY DIFFRACTION / Resolution: 2.7 Å

PDB-4ohi:
LEOPARD Syndrome-Associated SHP2/Q510E mutant
Method: X-RAY DIFFRACTION / Resolution: 2.2 Å

PDB-4ohl:
LEOPARD Syndrome-Associated SHP2/T468M mutant
Method: X-RAY DIFFRACTION / Resolution: 2.4 Å

Chemicals

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsHYDROLASE / SH2 DOMAIN / PHOSPHATASE DOMAIN

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