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TitleRational design, preparation, and characterization of a therapeutic enzyme mutant with improved stability and function for cocaine detoxification.
Journal, issue, pagesAcs Chem. Biol., Vol. 9, Page 1764-1772, Year 2014
Publish dateFeb 20, 2014 (structure data deposition date)
AuthorsFang, L. / Chow, K.M. / Hou, S. / Xue, L. / Chen, X. / Rodgers, D.W. / Zheng, F. / Zhan, C.G.
External linksAcs Chem. Biol. / PubMed:24919140
MethodsX-ray diffraction
Resolution2.341 Å
Structure data

PDB-4p08:
Engineered thermostable dimeric cocaine esterase
Method: X-RAY DIFFRACTION / Resolution: 2.341 Å

Chemicals

ChemComp-HOH:
WATER

Source
  • rhodococcus sp. (bacteria)
KeywordsHYDROLASE / esterase / disulfide-linked dimer / cocaine / mutant

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