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TitlePharmacologic Profile of the Adnectin BMS-962476, a Small Protein Biologic Alternative to PCSK9 Antibodies for Low-Density Lipoprotein Lowering.
Journal, issue, pagesJ. Pharmacol. Exp. Ther., Vol. 350, Page 412-424, Year 2014
Publish dateFeb 20, 2014 (structure data deposition date)
AuthorsMitchell, T. / Chao, G. / Sitkoff, D. / Lo, F. / Monshizadegan, H. / Meyers, D. / Low, S. / Russo, K. / DiBella, R. / Denhez, F. ...Mitchell, T. / Chao, G. / Sitkoff, D. / Lo, F. / Monshizadegan, H. / Meyers, D. / Low, S. / Russo, K. / DiBella, R. / Denhez, F. / Gao, M. / Myers, J. / Duke, G. / Witmer, M. / Miao, B. / Ho, S.P. / Khan, J. / Parker, R.A.
External linksJ. Pharmacol. Exp. Ther. / PubMed:24917546
MethodsX-ray diffraction
Resolution2.69 Å
Structure data

PDB-4ov6:
Crystal structure of PCSK9(53-451) with Adnectin
Method: X-RAY DIFFRACTION / Resolution: 2.69 Å

Chemicals

ChemComp-EDO:
1,2-ETHANEDIOL

ChemComp-PG4:
TETRAETHYLENE GLYCOL / precipitant*YM

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsHYDROLASE/PROTEIN BINDING / PCSK9 / Adnectin / LDL-cholesterol / HYDROLASE-PROTEIN BINDING complex

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