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Structure paper

TitleStructural and functional characterization of human and murine C5a anaphylatoxins.
Journal, issue, pagesActa Crystallogr. D Biol. Crystallogr., Vol. 70, Page 1704-1717, Year 2014
Publish dateMar 6, 2014 (structure data deposition date)
AuthorsSchatz-Jakobsen, J.A. / Yatime, L. / Larsen, C. / Petersen, S.V. / Klos, A. / Andersen, G.R.
External linksActa Crystallogr. D Biol. Crystallogr. / PubMed:24914981
MethodsX-ray diffraction
Resolution1.4 - 2.401 Å
Structure data

PDB-4p39:
Crystal structure of the human C5aR antagonist C5a-A8
Method: X-RAY DIFFRACTION / Resolution: 2.401 Å

PDB-4p3a:
Crystal structure of the mouse C5a anaphylatoxin
Method: X-RAY DIFFRACTION / Resolution: 1.4 Å

PDB-4p3b:
Crystal structure of the mouse C5a-desArg anaphylatoxin
Method: X-RAY DIFFRACTION / Resolution: 2.1 Å

Chemicals

ChemComp-HOH:
WATER

ChemComp-FMT:
FORMIC ACID

Source
  • homo sapiens (human)
  • mus musculus (house mouse)
KeywordsIMMUNE SYSTEM / complement anaphylatoxin / C5a / three-helix bundle / GPCR antagonist / four-helix bundle / GPCR agonist

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