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Title | Design and Synthesis of Phenylpyrrolidine Phenylglycinamides As Highly Potent and Selective TF-FVIIa Inhibitors. |
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Journal, issue, pages | ACS Med Chem Lett, Vol. 5, Page 188-192, Year 2014 |
Publish date | Nov 1, 2013 (structure data deposition date) |
Authors | Zhang, X. / Jiang, W. / Jacutin-Porte, S. / Glunz, P.W. / Zou, Y. / Cheng, X. / Nirschl, A.H. / Wurtz, N.R. / Luettgen, J.M. / Rendina, A.R. ...Zhang, X. / Jiang, W. / Jacutin-Porte, S. / Glunz, P.W. / Zou, Y. / Cheng, X. / Nirschl, A.H. / Wurtz, N.R. / Luettgen, J.M. / Rendina, A.R. / Luo, G. / Harper, T.M. / Wei, A. / Anumula, R. / Cheney, D.L. / Knabb, R.M. / Wong, P.C. / Wexler, R.R. / Priestley, E.S. |
External links | ACS Med Chem Lett / PubMed:24900796 |
Methods | X-ray diffraction |
Resolution | 2.15 - 2.2 Å |
Structure data | PDB-4ng9: PDB-4nga: |
Chemicals | ChemComp-2KE: ChemComp-CA: ChemComp-SO4: ChemComp-GOL: ChemComp-HOH: ChemComp-2KF: |
Source |
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Keywords | HYDROLASE/HYDROLASE INHIBITOR / GLYCOPROTEIN / HYDROLASE / SERINE PROTEASE / PLASMA / BLOOD COAGULATION FACTOR / PROTEIN INHIBITOR COMPLEX / CALCIUM-BINDING / HYDROLASE-HYDROLASE INHIBITOR complex |