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TitleDiscovery of RG7112: A Small-Molecule MDM2 Inhibitor in Clinical Development.
Journal, issue, pagesACS Med Chem Lett, Vol. 4, Page 466-469, Year 2013
Publish dateFeb 5, 2013 (structure data deposition date)
AuthorsVu, B. / Wovkulich, P. / Pizzolato, G. / Lovey, A. / Ding, Q. / Jiang, N. / Liu, J.J. / Zhao, C. / Glenn, K. / Wen, Y. ...Vu, B. / Wovkulich, P. / Pizzolato, G. / Lovey, A. / Ding, Q. / Jiang, N. / Liu, J.J. / Zhao, C. / Glenn, K. / Wen, Y. / Tovar, C. / Packman, K. / Vassilev, L. / Graves, B.
External linksACS Med Chem Lett / PubMed:24900694
MethodsX-ray diffraction
Resolution1.91 Å
Structure data

PDB-4j3e:
The 1.9A crystal structure of humanized Xenopus Mdm2 with nutlin-3a
Method: X-RAY DIFFRACTION / Resolution: 1.91 Å

Chemicals

ChemComp-NUT:
4-({(4S,5R)-4,5-bis(4-chlorophenyl)-2-[4-methoxy-2-(propan-2-yloxy)phenyl]-4,5-dihydro-1H-imidazol-1-yl}carbonyl)piperazin-2-one

ChemComp-SO4:
SULFATE ION

ChemComp-HOH:
WATER

Source
  • xenopus laevis (African clawed frog)
KeywordsLIGASE/ANTAGONIST / Mdm2 / protein-protein interaction / imidazoline / ligase-antagonist complex / E3 ubiquitin ligase / p53 / nucleus

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