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Structure paper

TitleCrystal structure and specific binding mode of sisomicin to the bacterial ribosomal decoding site.
Journal, issue, pagesAcs Med. Chem. Lett., Vol. 3, Page 741-744, Year 2012
Publish dateMay 18, 2012 (structure data deposition date)
AuthorsKondo, J. / Koganei, M. / Kasahara, T.
External linksAcs Med. Chem. Lett. / PubMed:24900542
MethodsX-ray diffraction
Resolution2 - 2.8 Å
Structure data

PDB-4f8u:
Crystal structure of the bacterial ribosomal decoding site in complex with sisomicin (C2 form)
Method: X-RAY DIFFRACTION / Resolution: 2 Å

PDB-4f8v:
Crystal structure of the bacterial ribosomal decoding site in complex with sisomicin (P21212 form)
Method: X-RAY DIFFRACTION / Resolution: 2.8 Å

Chemicals

ChemComp-SIS:
(1S,2S,3R,4S,6R)-4,6-diamino-3-{[(2S,3R)-3-amino-6-(aminomethyl)-3,4-dihydro-2H-pyran-2-yl]oxy}-2-hydroxycyclohexyl 3-deoxy-4-C-methyl-3-(methylamino)-beta-L-arabinopyranoside / antibiotic*YM

ChemComp-HOH:
WATER

KeywordsRNA/ANTIBIOTIC / decoding / ribosome / RNA-ANTIBIOTIC complex / decording

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