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-Structure paper
Title | Structure of a Dihydroxycoumarin Active-Site Inhibitor in Complex with the RNase H Domain of HIV-1 Reverse Transcriptase and Structure-Activity Analysis of Inhibitor Analogs. |
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Journal, issue, pages | J. Mol. Biol., Vol. 426, Page 2617-2631, Year 2014 |
Publish date | May 4, 2014 (structure data deposition date) |
Authors | Himmel, D.M. / Myshakina, N.S. / Ilina, T. / Van Ry, A. / Ho, W.C. / Parniak, M.A. / Arnold, E. |
External links | J. Mol. Biol. / PubMed:24840303 |
Methods | X-ray diffraction |
Resolution | 1.712 Å |
Structure data | PDB-4qag: |
Chemicals | ChemComp-MN: ChemComp-F95: ChemComp-HOH: |
Source |
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Keywords | HYDROLASE/HYDROLASE INHIBITOR / RNASE H INHIBITOR / STRUCTURE-BASED DRUG DESIGN / ACTIVE SITE / TRANSFERASE / DIHYDROXYCOUMARIN ANALOGS / DIHYDROXY-BENZOPYRONE DERIVATIVES / DIVALENT CATION CHELATOR / AIDS / REVERSE TRANSCRIPTASE / PROTEIN-INHIBITOR COMPLEX / HYDROLASE-HYDROLASE INHIBITOR complex |