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Structure paper

TitleInsight into the structural and biological relevance of the T/R transition of the N-terminus of the B-chain in human insulin.
Journal, issue, pagesBiochemistry, Vol. 53, Page 3392-3402, Year 2014
Publish dateMay 17, 2014 (structure data deposition date)
AuthorsKosinova, L. / Veverka, V. / Novotna, P. / Collinsova, M. / Urbanova, M. / Moody, N.R. / Turkenburg, J.P. / Jiracek, J. / Brzozowski, A.M. / Zakova, L.
External linksBiochemistry / PubMed:24819248
MethodsNMR (solution) / X-ray diffraction
Resolution1.4 - 1.7 Å
Structure data

PDB-2mpg:
Solution structure of the [AibB8,LysB28,ProB29]-insulin analogue
Method: SOLUTION NMR

PDB-4cxl:
Human insulin analogue (D-ProB8)-insulin
Method: X-RAY DIFFRACTION / Resolution: 1.5 Å

PDB-4cxn:
Crystal structure of human insulin analogue (NMe-AlaB8)-insulin crystal form I
Method: X-RAY DIFFRACTION / Resolution: 1.7 Å

PDB-4cy7:
Crystal structure of human insulin analogue (NMe-AlaB8)-insulin crystal form II
Method: X-RAY DIFFRACTION / Resolution: 1.4 Å

Chemicals

ChemComp-CL:
Unknown entry

ChemComp-HOH:
WATER

ChemComp-SO4:
SULFATE ION

ChemComp-ACT:
ACETATE ION

Source
  • homo sapiens (human)
KeywordsHORMONE / insulin analogue / DIABETES

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