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-Structure paper
Title | Orally Active 7-Substituted (4-Benzylphthalazin-1-yl)-2-methylpiperazin-1-yl]nicotinonitriles as Active-Site Inhibitors of Sphingosine 1-Phosphate Lyase for the Treatment of Multiple Sclerosis. |
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Journal, issue, pages | J. Med. Chem., Vol. 57, Page 5074-5084, Year 2014 |
Publish date | Apr 23, 2014 (structure data deposition date) |
Authors | Weiler, S. / Braendlin, N. / Beerli, C. / Bergsdorf, C. / Schubart, A. / Srinivas, H. / Oberhauser, B. / Billich, A. |
External links | J. Med. Chem. / PubMed:24809814 |
Methods | X-ray diffraction |
Resolution | 2.4 Å |
Structure data | PDB-4q6r: |
Chemicals | ChemComp-SIN: ChemComp-GOL: ChemComp-30J: ChemComp-PO4: ChemComp-HOH: |
Source |
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Keywords | Lyase/Lyase inhibitor / PLP / pyridoxal 5-phosphate-dependent enzymes / Lyase-Lyase inhibitor complex |