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TitleProteolytic Degradation of Topoisomerase II (Top2) Enables the Processing of Top2DNA and Top2RNA Covalent Complexes by Tyrosyl-DNA-Phosphodiesterase 2 (TDP2).
Journal, issue, pagesJ. Biol. Chem., Vol. 289, Page 17960-17969, Year 2014
Publish dateMar 13, 2014 (structure data deposition date)
AuthorsGao, R. / Schellenberg, M.J. / Huang, S.Y. / Abdelmalak, M. / Marchand, C. / Nitiss, K.C. / Nitiss, J.L. / Williams, R.S. / Pommier, Y.
External linksJ. Biol. Chem. / PubMed:24808172
MethodsX-ray diffraction
Resolution1.6 Å
Structure data

PDB-4puq:
Mus Musculus Tdp2 reaction product complex with 5'-phosphorylated RNA/DNA, glycerol, and Mg2+
Method: X-RAY DIFFRACTION / Resolution: 1.6 Å

Chemicals

ChemComp-MG:
Unknown entry

ChemComp-GOL:
GLYCEROL

ChemComp-ACT:
ACETATE ION

ChemComp-HOH:
WATER

Source
  • mus musculus (house mouse)
KeywordsHYDROLASE/DNA/RNA / protein-DNA complex / DNA repair / 5'-DNA end processing / EEP domain / Hydrolase / Metalloenzyme / 5'-DNA end recognition / HYDROLASE-DNA-RNA complex

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