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TitleCrystal structure of the histone lysine specific demethylase LSD1 complexed with tetrahydrofolate.
Journal, issue, pagesProtein Sci., Vol. 23, Page 993-998, Year 2014
Publish dateMay 22, 2013 (structure data deposition date)
AuthorsLuka, Z. / Pakhomova, S. / Loukachevitch, L.V. / Calcutt, M.W. / Newcomer, M.E. / Wagner, C.
External linksProtein Sci. / PubMed:24715612
MethodsX-ray diffraction
Resolution3.05 Å
Structure data

PDB-4kum:
Structure of LSD1-CoREST-Tetrahydrofolate complex
Method: X-RAY DIFFRACTION / Resolution: 3.05 Å

Chemicals

ChemComp-FAD:
FLAVIN-ADENINE DINUCLEOTIDE / FAD*YM

ChemComp-GOL:
GLYCEROL

ChemComp-THG:
(6S)-5,6,7,8-TETRAHYDROFOLATE

ChemComp-CL:
Unknown entry

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsOXIDOREDUCTASE/TRANSCRIPTION REGULATOR / Histone demethylase / Folate Binding / Chromatin / nucleosomes / OXIDOREDUCTASE-TRANSCRIPTION REGULATOR complex

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