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TitleStructural basis for the assembly of the mitotic motor Kinesin-5 into bipolar tetramers.
Journal, issue, pagesElife, Vol. 3, Page e02217-e02217, Year 2014
Publish dateMar 25, 2014 (structure data deposition date)
AuthorsScholey, J.E. / Nithianantham, S. / Scholey, J.M. / Al-Bassam, J.
External linksPubMed:24714498
MethodsX-ray diffraction
Resolution2.601 - 2.9 Å
Structure data

PDB-4pxt:
Structural basis for the assembly of the mitotic motor kinesin-5 into bipolar tetramers
Method: X-RAY DIFFRACTION / Resolution: 2.9 Å

PDB-4pxu:
Structural basis for the assembly of the mitotic motor kinesin-5 into bipolar tetramers
Method: X-RAY DIFFRACTION / Resolution: 2.601 Å

Chemicals

ChemComp-MPD:
(4S)-2-METHYL-2,4-PENTANEDIOL / precipitant*YM

ChemComp-HOH:
WATER

Source
  • drosophila melanogaster (fruit fly)
KeywordsCELL CYCLE / Coiled-coil / Bipolar assembly domain of kinesin-5 / bipolar tetramers / anti-parallel four-helix bundle / Kinesin-5 functions via a "sliding filament" mechanism / crosslinking adjacent microtubules into bundles throughout the mitotic spindle / Microtubules

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