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Structure paper

TitleStructure and Function of RNase AS, a Polyadenylate-Specific Exoribonuclease Affecting Mycobacterial Virulence In Vivo
Journal, issue, pagesStructure, Vol. 22, Page 719-730, Year 2014
Publish dateJan 22, 2014 (structure data deposition date)
AuthorsRomano, M. / van de Weerd, R. / Brouwer, F.C.C. / Roviello, G.N. / Lacroix, R. / Sparrius, M. / van den Brink-van Stempvoort, G. / Maaskant, J.J. / van der Sar, A.M. / Appelmelk, B.J. ...Romano, M. / van de Weerd, R. / Brouwer, F.C.C. / Roviello, G.N. / Lacroix, R. / Sparrius, M. / van den Brink-van Stempvoort, G. / Maaskant, J.J. / van der Sar, A.M. / Appelmelk, B.J. / Geurtsen, J.J. / Berisio, R.
External linksStructure / PubMed:24704253
MethodsX-ray diffraction
Resolution1.7 - 2.21 Å
Structure data

PDB-4oke:
Structure of RNase AS, a polyadenylate-specific exoribonuclease affecting mycobacterial virulence in vivo
Method: X-RAY DIFFRACTION / Resolution: 1.7 Å

PDB-4okj:
Crystal structure of RNase AS from M tuberculosis
Method: X-RAY DIFFRACTION / Resolution: 2.1 Å

PDB-4okk:
Crystal structure of RNase AS from M tuberculosis in complex with UMP
Method: X-RAY DIFFRACTION / Resolution: 2.21 Å

Chemicals

ChemComp-AMP:
ADENOSINE MONOPHOSPHATE / AMP*YM

ChemComp-MG:
Unknown entry

ChemComp-HOH:
WATER

ChemComp-U5P:
URIDINE-5'-MONOPHOSPHATE

Source
  • mycobacterium tuberculosis (bacteria)
KeywordsHYDROLASE / M. tuberculosis / ribonuclease / capsular polysaccharides / virulence / alpha/beta fold / exoribonuclease

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