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TitleTetra-substituted imidazoles as a new class of inhibitors of the p53-MDM2 interaction.
Journal, issue, pagesBioorg. Med. Chem. Lett., Vol. 24, Page 2110-2114, Year 2014
Publish dateFeb 7, 2014 (structure data deposition date)
AuthorsVaupel, A. / Bold, G. / De Pover, A. / Stachyra-Valat, T. / Hergovich-Lisztwan, J. / Kallen, J. / Masuya, K. / Furet, P.
External linksBioorg. Med. Chem. Lett. / PubMed:24704029
MethodsX-ray diffraction
Resolution2.3 Å
Structure data

PDB-4oq3:
Tetra-substituted imidazoles as a new class of inhibitors of the p53-MDM2 interaction
Method: X-RAY DIFFRACTION / Resolution: 2.3 Å

Chemicals

ChemComp-2V8:
1-(5-chloro-2-methylphenyl)-5-(3-chlorophenyl)-2-(3-methylphenyl)-1H-imidazole-4-carboxylic acid

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsLIGASE/LIGASE INHIBITOR / PPI WITH P53 / INHIBITOR COMPLEX / LIGASE-LIGASE INHIBITOR complex

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