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-Structure paper
タイトル | Structure of the yeast mitochondrial large ribosomal subunit. |
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ジャーナル・号・ページ | Science, Vol. 343, Issue 6178, Page 1485-1489, Year 2014 |
掲載日 | 2014年3月28日 |
![]() | Alexey Amunts / Alan Brown / Xiao-Chen Bai / Jose L Llácer / Tanweer Hussain / Paul Emsley / Fei Long / Garib Murshudov / Sjors H W Scheres / V Ramakrishnan / ![]() |
PubMed 要旨 | Mitochondria have specialized ribosomes that have diverged from their bacterial and cytoplasmic counterparts. We have solved the structure of the yeast mitoribosomal large subunit using single- ...Mitochondria have specialized ribosomes that have diverged from their bacterial and cytoplasmic counterparts. We have solved the structure of the yeast mitoribosomal large subunit using single-particle cryo-electron microscopy. The resolution of 3.2 angstroms enabled a nearly complete atomic model to be built de novo and refined, including 39 proteins, 13 of which are unique to mitochondria, as well as expansion segments of mitoribosomal RNA. The structure reveals a new exit tunnel path and architecture, unique elements of the E site, and a putative membrane docking site. |
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手法 | EM (単粒子) |
解像度 | 3.2 Å |
構造データ | |
化合物 | ![]() ChemComp-MG: ![]() ChemComp-NA: ![]() ChemComp-ZN: |
由来 |
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![]() | RIBOSOME / mitochondrial ribosome / large subunit / protein-RNA complex |