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TitleOmarigliptin (MK-3102): A Novel Long-Acting DPP-4 Inhibitor for Once-Weekly Treatment of Type 2 Diabetes.
Journal, issue, pagesJ. Med. Chem., Vol. 57, Page 3205-3212, Year 2014
Publish dateFeb 22, 2014 (structure data deposition date)
AuthorsBiftu, T. / Sinha-Roy, R. / Chen, P. / Qian, X. / Feng, D. / Kuethe, J.T. / Scapin, G. / Gao, Y.D. / Yan, Y. / Krueger, D. ...Biftu, T. / Sinha-Roy, R. / Chen, P. / Qian, X. / Feng, D. / Kuethe, J.T. / Scapin, G. / Gao, Y.D. / Yan, Y. / Krueger, D. / Bak, A. / Eiermann, G. / He, J. / Cox, J. / Hicks, J. / Lyons, K. / He, H. / Salituro, G. / Tong, S. / Patel, S. / Doss, G. / Petrov, A. / Wu, J. / Xu, S.S. / Sewall, C. / Zhang, X. / Zhang, B. / Thornberry, N.A. / Weber, A.E.
External linksJ. Med. Chem. / PubMed:24660890
MethodsX-ray diffraction
Resolution1.9 Å
Structure data

PDB-4pnz:
Human dipeptidyl peptidase IV/CD26 in complex with the long-acting inhibitor Omarigliptin (MK-3102)
Method: X-RAY DIFFRACTION / Resolution: 1.9 Å

Chemicals

ChemComp-NA:
Unknown entry

ChemComp-2VH:
(2R,3S,5R)-5-[2-(methylsulfonyl)-2,6-dihydropyrrolo[3,4-c]pyrazol-5(4H)-yl]-2-(2,4,5-trifluorophenyl)tetrahydro-2H-pyran-3-amine

ChemComp-NAG:
2-acetamido-2-deoxy-beta-D-glucopyranose

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsHYDROLASE/HYDROLASE INHIBITOR / alpha/beta / beta-propeller / dimer / diabetes / aminopeptidase / cell membrane / disulfide bond / glycoprotein / secreted / serine protease / signal-anchor / transmembrane / HYDROLASE-HYDROLASE INHIBITOR complex

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