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TitlePPNDS inhibits murine Norovirus RNA-dependent RNA-polymerase mimicking two RNA stacking bases.
Journal, issue, pagesFebs Lett., Vol. 588, Page 1720-1725, Year 2014
Publish dateDec 19, 2013 (structure data deposition date)
AuthorsCroci, R. / Tarantino, D. / Milani, M. / Pezzullo, M. / Rohayem, J. / Bolognesi, M. / Mastrangelo, E.
External linksFebs Lett. / PubMed:24657439
MethodsX-ray diffraction
Resolution2.4 Å
Structure data

PDB-4o4r:
Murine Norovirus RdRp in complex with PPNDS
Method: X-RAY DIFFRACTION / Resolution: 2.4 Å

Chemicals

ChemComp-20V:
3-[(E)-{4-formyl-5-hydroxy-6-methyl-3-[(phosphonooxy)methyl]pyridin-2-yl}diazenyl]-7-nitronaphthalene-1,5-disulfonic

ChemComp-SO4:
SULFATE ION

ChemComp-HOH:
WATER

Source
  • murine norovirus 1
KeywordsVIRAL PROTEIN/REPLICATION INHIBITOR / RNA-dependent-RNA-polymerase / RNA binding / VIRAL PROTEIN-REPLICATION INHIBITOR complex

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