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TitleInhibition of Both Focal Adhesion Kinase and Fibroblast Growth Factor Receptor 2 Pathways Induces Anti-Tumor and Anti-Angiogenic Activities.
Journal, issue, pagesCancer Lett., Vol. 348, Page 88-, Year 2014
Publish dateSep 25, 2013 (structure data deposition date)
AuthorsDao, P. / Jarray, R. / Smith, N. / Lepelletier, Y. / Le Coq, J. / Lietha, D. / Hadj-Slimane, R. / Herbeuval, J.P. / Garbay, C. / Raynaud, F. / Chen, H.
External linksCancer Lett. / PubMed:24657306
MethodsX-ray diffraction
Resolution2.05 Å
Structure data

PDB-4c7t:
Focal Adhesion Kinase catalytic domain in complex with a diarylamino- 1,3,5-triazine inhibitor
Method: X-RAY DIFFRACTION / Resolution: 2.05 Å

Chemicals

ChemComp-5RI:
N-methyl-2-[[4-[(3,4,5-trimethoxyphenyl)amino]-1,3,5-triazin-2-yl]amino]benzamide

ChemComp-SO4:
SULFATE ION

ChemComp-HOH:
WATER

Source
  • gallus gallus (chicken)
KeywordsTRANSFERASE / KINASE INHIBITOR / ATP-BINDING / INTEGRIN SIGNALING

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