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Structure paper

TitleSelective methylation of histone H3 variant H3.1 regulates heterochromatin replication.
Journal, issue, pagesScience, Vol. 343, Page 1249-1253, Year 2014
Publish dateDec 17, 2013 (structure data deposition date)
AuthorsJacob, Y. / Bergamin, E. / Donoghue, M.T. / Mongeon, V. / LeBlanc, C. / Voigt, P. / Underwood, C.J. / Brunzelle, J.S. / Michaels, S.D. / Reinberg, D. ...Jacob, Y. / Bergamin, E. / Donoghue, M.T. / Mongeon, V. / LeBlanc, C. / Voigt, P. / Underwood, C.J. / Brunzelle, J.S. / Michaels, S.D. / Reinberg, D. / Couture, J.F. / Martienssen, R.A.
External linksScience / PubMed:24626927
MethodsX-ray diffraction
Resolution2.1 Å
Structure data

PDB-4o30:
Crystal structure of ATXR5 in complex with histone H3.1 and AdoHcy
Method: X-RAY DIFFRACTION / Resolution: 2.1 Å

Chemicals

ChemComp-SAH:
S-ADENOSYL-L-HOMOCYSTEINE

ChemComp-DMS:
DIMETHYL SULFOXIDE / DMSO, precipitant*YM

ChemComp-BME:
BETA-MERCAPTOETHANOL

ChemComp-HOH:
WATER

Source
  • ricinus communis (castor bean)
KeywordsTRANSFERASE / histone methylation / chromatin / epigenetics / trithorax / SET domain / lysine methyltransferases / PCNA / histone H3 / nucleus

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