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Structure paper

TitleStructural bases of norovirus RNA dependent RNA polymerase inhibition by novel suramin-related compounds.
Journal, issue, pagesPlos One, Vol. 9, Page e91765-e91765, Year 2014
Publish dateNov 27, 2013 (structure data deposition date)
AuthorsCroci, R. / Pezzullo, M. / Tarantino, D. / Milani, M. / Tsay, S.C. / Sureshbabu, R. / Tsai, Y.J. / Mastrangelo, E. / Rohayem, J. / Bolognesi, M. / Hwu, J.R.
External linksPlos One / PubMed:24622391
MethodsX-ray diffraction
Resolution2.022 - 2.3 Å
Structure data

PDB-4nrt:
Human Norovirus polymerase bound to Compound 6 (suramin derivative)
Method: X-RAY DIFFRACTION / Resolution: 2.022 Å

PDB-4nru:
Murine Norovirus RNA-dependent-RNA-polymerase in complex with Compound 6, a suramin derivative
Method: X-RAY DIFFRACTION / Resolution: 2.3 Å

Chemicals

ChemComp-2NG:
4-({4-methyl-3-[(3-nitrobenzoyl)amino]benzoyl}amino)naphthalene-1,5-disulfonic acid

ChemComp-HOH:
WATER

ChemComp-MG:
Unknown entry

Source
  • norwalk-like virus
  • murine norovirus 1
KeywordsVIRAL PROTEIN/TRANSCRIPTION INHIBITOR / RNA dependent RNA Polymerase / VIRAL PROTEIN-TRANSCRIPTION INHIBITOR complex / Murine Norovirus

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