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TitleMechanism of the C5 stereoinversion reaction in the biosynthesis of carbapenem antibiotics.
Journal, issue, pagesScience, Vol. 343, Page 1140-1144, Year 2014
Publish dateJan 20, 2014 (structure data deposition date)
AuthorsChang, W.C. / Guo, Y. / Wang, C. / Butch, S.E. / Rosenzweig, A.C. / Boal, A.K. / Krebs, C. / Bollinger, J.M.
External linksScience / PubMed:24604200
MethodsX-ray diffraction
Resolution2.1 Å
Structure data

PDB-4oj8:
Crystal structure of carbapenem synthase in complex with (3S,5S)-carbapenam
Method: X-RAY DIFFRACTION / Resolution: 2.1 Å

Chemicals

ChemComp-FE2:
Unknown entry

ChemComp-AKG:
2-OXOGLUTARIC ACID

ChemComp-GOL:
GLYCEROL

ChemComp-2TQ:
(2S,5S)-7-oxo-1-azabicyclo[3.2.0]heptane-2-carboxylic acid

ChemComp-HOH:
WATER

Source
  • pectobacterium carotovorum subsp. carotovorum (bacteria)
KeywordsOXIDOREDUCTASE / oxygenase / iron / 2-oxoglutaric acid / antibiotic biosynthesis / carbapenam

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