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Structure paper

TitleMechanism of IRSp53 inhibition and combinatorial activation by Cdc42 and downstream effectors.
Journal, issue, pagesNat. Struct. Mol. Biol., Vol. 21, Page 413-422, Year 2014
Publish dateMar 22, 2013 (structure data deposition date)
AuthorsKast, D.J. / Yang, C. / Disanza, A. / Boczkowska, M. / Madasu, Y. / Scita, G. / Svitkina, T. / Dominguez, R.
External linksNat. Struct. Mol. Biol. / PubMed:24584464
MethodsX-ray diffraction
Resolution1.9 Å
Structure data

PDB-4js0:
Complex of Cdc42 with the CRIB-PR domain of IRSp53
Method: X-RAY DIFFRACTION / Resolution: 1.9 Å

Chemicals

ChemComp-GNP:
PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER / GppNHp, GMPPNP, energy-carrying molecule analogue*YM

ChemComp-MG:
Unknown entry

ChemComp-PE4:
2-{2-[2-(2-{2-[2-(2-ETHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHOXY)-ETHOXY]-ETHOXY}-ETHANOL / precipitant*YM

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsSIGNALING PROTEIN/SIGNALING PROTEIN / GTPase binding domain / CRIB domain / cytoskeleton regulation / SIGNALING PROTEIN-SIGNALING PROTEIN complex

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