+Search query
-Structure paper
Title | Approach for targeting Ras with small molecules that activate SOS-mediated nucleotide exchange. |
---|---|
Journal, issue, pages | Proc. Natl. Acad. Sci. USA, Vol. 111, Page 3401-3406, Year 2014 |
Publish date | Dec 10, 2013 (structure data deposition date) |
![]() | Burns, M.C. / Sun, Q. / Daniels, R.N. / Camper, D. / Kennedy, J.P. / Phan, J. / Olejniczak, E.T. / Lee, T. / Waterson, A.G. / Rossanese, O.W. / Fesik, S.W. |
![]() | ![]() ![]() |
Methods | X-ray diffraction |
Resolution | 2.8522 - 3.5529 Å |
Structure data | ![]() PDB-4nyi: ![]() PDB-4nyj: ![]() PDB-4nym: |
Chemicals | ![]() ChemComp-MG: ![]() ChemComp-GNP: ![]() ChemComp-2PX: ![]() ChemComp-HOH: ![]() ChemComp-2PZ: ![]() ChemComp-RND: |
Source |
|
![]() | SIGNALING PROTEIN / Ras SOS complex / signal transduction / Raf / PI3K / poly-petide / cytosol / GTPase / signaling transduction / RalGDS |