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| Title | Selective and Potent Morpholinone Inhibitors of the MDM2-p53 Protein-Protein Interaction. |
|---|---|
| Journal, issue, pages | J. Med. Chem., Vol. 57, Page 2472-2488, Year 2014 |
| Publish date | Jan 7, 2014 (structure data deposition date) |
 Authors | Gonzalez, A.Z. / Eksterowicz, J. / Bartberger, M.D. / Beck, H.P. / Canon, J. / Chen, A. / Chow, D. / Duquette, J. / Fox, B.M. / Fu, J. ...Gonzalez, A.Z. / Eksterowicz, J. / Bartberger, M.D. / Beck, H.P. / Canon, J. / Chen, A. / Chow, D. / Duquette, J. / Fox, B.M. / Fu, J. / Huang, X. / Houze, J.B. / Jin, L. / Li, Y. / Li, Z. / Ling, Y. / Lo, M.C. / Long, A.M. / McGee, L.R. / McIntosh, J. / McMinn, D.L. / Oliner, J.D. / Osgood, T. / Rew, Y. / Saiki, A.Y. / Shaffer, P. / Wortman, S. / Yakowec, P. / Yan, X. / Ye, Q. / Yu, D. / Zhao, X. / Zhou, J. / Olson, S.H. / Medina, J.C. / Sun, D. |
 External links | J. Med. Chem. / PubMed:24548297 |
| Methods | X-ray diffraction |
| Resolution | 1.602 Å |
| Structure data |  PDB-4oba: |
| Chemicals |  ChemComp-2TW:  ChemComp-HOH: |
| Source |
|
 Keywords | ligase/ligase inhibitor / P53 / PROTEIN-PROTEIN INTERACTION / LIGASE-LIGASE INHIBITOR COMPLEX |
homo sapiens (human)