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| Title | Discovery of AMG 232, a Potent, Selective, and Orally Bioavailable MDM2-p53 Inhibitor in Clinical Development. |
|---|---|
| Journal, issue, pages | J. Med. Chem., Vol. 57, Page 1454-1472, Year 2014 |
| Publish date | Jan 6, 2014 (structure data deposition date) |
 Authors | Sun, D. / Li, Z. / Rew, Y. / Gribble, M. / Bartberger, M.D. / Beck, H.P. / Canon, J. / Chen, A. / Chen, X. / Chow, D. ...Sun, D. / Li, Z. / Rew, Y. / Gribble, M. / Bartberger, M.D. / Beck, H.P. / Canon, J. / Chen, A. / Chen, X. / Chow, D. / Deignan, J. / Duquette, J. / Eksterowicz, J. / Fisher, B. / Fox, B.M. / Fu, J. / Gonzalez, A.Z. / Gonzalez-Lopez De Turiso, F. / Houze, J.B. / Huang, X. / Jiang, M. / Jin, L. / Kayser, F. / Liu, J.J. / Lo, M.C. / Long, A.M. / Lucas, B. / McGee, L.R. / McIntosh, J. / Mihalic, J. / Oliner, J.D. / Osgood, T. / Peterson, M.L. / Roveto, P. / Saiki, A.Y. / Shaffer, P. / Toteva, M. / Wang, Y. / Wang, Y.C. / Wortman, S. / Yakowec, P. / Yan, X. / Ye, Q. / Yu, D. / Yu, M. / Zhao, X. / Zhou, J. / Zhu, J. / Olson, S.H. / Medina, J.C. |
 External links | J. Med. Chem. / PubMed:24456472 |
| Methods | X-ray diffraction |
| Resolution | 1.7 Å |
| Structure data |  PDB-4oas: |
| Chemicals |  ChemComp-2SW:  ChemComp-SO4:  ChemComp-HOH: |
| Source |
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 Keywords | ligase/ligase inhibitor / MDM2. 53 / protein-protein interaction / inhibitor / ligase-ligase inhibitor complex |
homo sapiens (human)