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TitleDesign and Synthesis of Truncated EGF-A Peptides that Restore LDL-R Recycling in the Presence of PCSK9 In Vitro.
Journal, issue, pagesChem. Biol., Vol. 21, Page 284-294, Year 2014
Publish dateOct 30, 2013 (structure data deposition date)
AuthorsSchroeder, C.I. / Swedberg, J.E. / Withka, J.M. / Rosengren, K.J. / Akcan, M. / Clayton, D.J. / Daly, N.L. / Cheneval, O. / Borzilleri, K.A. / Griffor, M. ...Schroeder, C.I. / Swedberg, J.E. / Withka, J.M. / Rosengren, K.J. / Akcan, M. / Clayton, D.J. / Daly, N.L. / Cheneval, O. / Borzilleri, K.A. / Griffor, M. / Stock, I. / Colless, B. / Walsh, P. / Sunderland, P. / Reyes, A. / Dullea, R. / Ammirati, M. / Liu, S. / McClure, K.F. / Tu, M. / Bhattacharya, S.K. / Liras, S. / Price, D.A. / Craik, D.J.
External linksChem. Biol. / PubMed:24440079
MethodsNMR (solution) / X-ray diffraction
Resolution2.6 Å
Structure data

PDB-2mg9:
Truncated EGF-A
Method: SOLUTION NMR

PDB-4ne9:
PCSK9 in complex with LDLR peptide
Method: X-RAY DIFFRACTION / Resolution: 2.6 Å

Chemicals

ChemComp-CA:
Unknown entry

ChemComp-NAG:
2-acetamido-2-deoxy-beta-D-glucopyranose

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsMETAL BINDING PROTEIN / EGF-A / disulfide rich / HYDROLASE / PCSK9 / LDL RECEPTOR / AUTOCATALYTIC CLEAVAGE / CHOLESTEROL METABOLISM

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