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TitleDiscovery of MK-7655, a beta-lactamase inhibitor for combination with Primaxin().
Journal, issue, pagesBioorg. Med. Chem. Lett., Vol. 24, Page 780-785, Year 2014
Publish dateNov 12, 2013 (structure data deposition date)
AuthorsBlizzard, T.A. / Chen, H. / Kim, S. / Wu, J. / Bodner, R. / Gude, C. / Imbriglio, J. / Young, K. / Park, Y.W. / Ogawa, A. ...Blizzard, T.A. / Chen, H. / Kim, S. / Wu, J. / Bodner, R. / Gude, C. / Imbriglio, J. / Young, K. / Park, Y.W. / Ogawa, A. / Raghoobar, S. / Hairston, N. / Painter, R.E. / Wisniewski, D. / Scapin, G. / Fitzgerald, P. / Sharma, N. / Lu, J. / Ha, S. / Hermes, J. / Hammond, M.L.
External linksBioorg. Med. Chem. Lett. / PubMed:24433862
MethodsX-ray diffraction
Resolution1.9 Å
Structure data

PDB-4nk3:
Amp-c beta-lactamase (pseudomonas aeruginosa) in complex with mk-7655
Method: X-RAY DIFFRACTION / Resolution: 1.9 Å

Chemicals

ChemComp-MK7:
(2S,5R)-1-formyl-N-(piperidin-4-yl)-5-[(sulfooxy)amino]piperidine-2-carboxamide

ChemComp-HOH:
WATER

Source
  • pseudomonas aeruginosa (bacteria)
KeywordsHYDROLASE/HYDROLASE INHIBITOR / HYDROLASE / HYDROLASE-HYDROLASE INHIBITOR COMPLEX

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