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TitleAffinity improvement of a therapeutic antibody to methamphetamine and amphetamine through structure-based antibody engineering.
Journal, issue, pagesSci Rep, Vol. 4, Page 3673-3673, Year 2014
Publish dateAug 23, 2012 (structure data deposition date)
AuthorsThakkar, S. / Nanaware-Kharade, N. / Celikel, R. / Peterson, E.C. / Varughese, K.I.
External linksSci Rep / PubMed:24419156
MethodsX-ray diffraction
Resolution2 Å
Structure data

PDB-4gqp:
Structure based design of sub-nanomolar affinity anti-methamphetamine single chain antibodies.
Method: X-RAY DIFFRACTION / Resolution: 2 Å

Chemicals

ChemComp-B40:
(2S)-N-methyl-1-phenylpropan-2-amine

ChemComp-HOH:
WATER

Source
  • mus musculus (house mouse)
KeywordsIMMUNE SYSTEM / Antibody METH complex / Immunoglobulin fold / anti-METH single chain antibody / free METH concentration / Methamphetamine / vasculature

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