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TitleHigh-resolution structures and orientations of antimicrobial peptides piscidin 1 and piscidin 3 in fluid bilayers reveal tilting, kinking, and bilayer immersion.
Journal, issue, pagesJ. Am. Chem. Soc., Vol. 136, Page 3491-3504, Year 2014
Publish dateAug 27, 2013 (structure data deposition date)
AuthorsPerrin, B.S. / Tian, Y. / Fu, R. / Grant, C.V. / Chekmenev, E.Y. / Wieczorek, W.E. / Dao, A.E. / Hayden, R.M. / Burzynski, C.M. / Venable, R.M. ...Perrin, B.S. / Tian, Y. / Fu, R. / Grant, C.V. / Chekmenev, E.Y. / Wieczorek, W.E. / Dao, A.E. / Hayden, R.M. / Burzynski, C.M. / Venable, R.M. / Sharma, M. / Opella, S.J. / Pastor, R.W. / Cotten, M.L.
External linksJ. Am. Chem. Soc. / PubMed:24410116
MethodsNMR (solid-state)
Structure data

PDB-2mcu:
Solid-state NMR structure of piscidin 1 in aligned 3:1 phosphatidylcholine/phosphoglycerol lipid bilayers
Method: SOLID-STATE NMR

PDB-2mcv:
Solid-state NMR structure of piscidin 1 in aligned 1:1 phosphatidylethanolamine/phosphoglycerol lipid bilayers
Method: SOLID-STATE NMR

PDB-2mcw:
Solid-state NMR structure of piscidin 3 in aligned 3:1 phosphatidylcholine/phosphoglycerol lipid bilayers
Method: SOLID-STATE NMR

PDB-2mcx:
Solid-state NMR structure of piscidin 3 in aligned 1:1 phosphatidylethanolamine/phosphoglycerol lipid bilayers
Method: SOLID-STATE NMR

Source
  • morone saxatilis (striped sea-bass)
  • morone chrysops x morone saxatilis (white bass x striped sea-bass)
KeywordsANTIMICROBIAL PROTEIN / antimicrobial peptide / anticancer peptide / anti HIV-1 / cationic / amphipathic / histidine rich / helical / lipid bilayers / bacterial cell membrane mimic

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