タイトル | Systematic Comparison of Peptidic Proteasome Inhibitors Highlights the alpha-Ketoamide Electrophile as an Auspicious Reversible Lead Motif. |
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ジャーナル・号・ページ | Angew. Chem. Int. Ed. Engl., Vol. 53, Page 1679-1683, Year 2014 |
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掲載日 | 2013年11月18日 (構造データの登録日) |
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著者 | Stein, M.L. / Cui, H. / Beck, P. / Dubiella, C. / Voss, C. / Kruger, A. / Schmidt, B. / Groll, M. |
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リンク | Angew. Chem. Int. Ed. Engl. / PubMed:24403024 |
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手法 | X線回折 |
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解像度 | 2.5 - 3 Å |
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構造データ | PDB-4nnn: yCP in complex with MG132 手法: X-RAY DIFFRACTION / 解像度: 2.5 Å PDB-4nnw: yCP in complex with Z-Leu-Leu-Leu-ketoaldehyde 手法: X-RAY DIFFRACTION / 解像度: 2.6 Å PDB-4no1: yCP in complex with Z-Leu-Leu-Leu-B(OH)2 手法: X-RAY DIFFRACTION / 解像度: 2.5 Å PDB-4no6: yCP in complex with Z-Leu-Leu-Leu-vinylsulfone 手法: X-RAY DIFFRACTION / 解像度: 3 Å PDB-4no8: yCP in complex with Z-Leu-Leu-Leu-ketoamide 手法: X-RAY DIFFRACTION / 解像度: 2.7 Å PDB-4no9: yCP in complex with Z-Leu-Leu-Leu-epoxyketone 手法: X-RAY DIFFRACTION / 解像度: 2.9 Å |
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化合物 | ChemComp-ALD: N-[(benzyloxy)carbonyl]-L-leucyl-N-[(2S)-1-hydroxy-4-methylpentan-2-yl]-L-leucinamide
ChemComp-2MK: N-[(benzyloxy)carbonyl]-L-leucyl-N-[(2R,3S)-1,2-dihydroxy-5-methylhexan-3-yl]-L-leucinamide
ChemComp-CIX: N-[(benzyloxy)carbonyl]-L-leucyl-N-[(1R)-1-(dihydroxyboranyl)-3-methylbutyl]-L-leucinamide / MG-262
ChemComp-2M1: N-[(benzyloxy)carbonyl]-L-leucyl-N-[(3S)-5-methyl-1-(methylsulfonyl)hexan-3-yl]-L-leucinamide
ChemComp-2LV: N-[(benzyloxy)carbonyl]-L-leucyl-N-[(2S,3S)-2-hydroxy-5-methyl-1-oxo-1-(phenylamino)hexan-3-yl]-L-leucinamide
ChemComp-2L0: N-[(benzyloxy)carbonyl]-L-leucyl-N-[(2R,3S,4S)-1,3-dihydroxy-2,6-dimethylheptan-4-yl]-L-leucinamide
ChemComp-2LR: N-[(benzyloxy)carbonyl]-L-leucyl-N-{(1R,2S)-1-hydroxy-4-methyl-1-[(2R)-2-methyloxiran-2-yl]pentan-2-yl}-L-leucinamide
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由来 | ![](img/tx_yeast.gif) saccharomyces cerevisiae s288c (パン酵母)![](img/tx_yeast.gif) saccharomyces cerevisiae (パン酵母)
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キーワード | HYDROLASE/HYDROLASE Inhibitor / Proteasome / Peptide Electrophile / Binding Analysis / Reversible Inhibitor / Aldehyde / HYDROLASE-HYDROLASE Inhibitor complex / Ketoaldehyde / Irreversible Inhibitor / Boronic acid / Vinylsulfone / Ketoamide / Epoxyketone |
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