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TitleStructural Basis for Potent Inhibition of SIRT2 Deacetylase by a Macrocyclic Peptide Inducing Dynamic Structural Change
Journal, issue, pagesStructure, Vol. 22, Page 345-352, Year 2013
Publish dateJun 6, 2013 (structure data deposition date)
AuthorsYamagata, K. / Goto, Y. / Nishimasu, H. / Morimoto, J. / Ishitani, R. / Dohmae, N. / Takeda, N. / Nagai, R. / Komuro, I. / Suga, H. / Nureki, O.
External linksStructure / PubMed:24389023
MethodsX-ray diffraction
Resolution2.518 Å
Structure data

PDB-4l3o:
Crystal Structure of SIRT2 in complex with the macrocyclic peptide S2iL5
Method: X-RAY DIFFRACTION / Resolution: 2.518 Å

Chemicals

ChemComp-ZN:
Unknown entry

ChemComp-MES:
2-(N-MORPHOLINO)-ETHANESULFONIC ACID / pH buffer*YM

ChemComp-EDO:
1,2-ETHANEDIOL

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsHYDROLASE/HYDROLASE INHIBITOR / macrocyclic peptide / structural change / HYDROLASE-HYDROLASE INHIBITOR complex

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