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TitleCytokine Spatzle Binds to the Drosophila Immunoreceptor Toll with a Neurotrophin-Like Specificity and Couples Receptor Activation.
Journal, issue, pagesProc. Natl. Acad. Sci. USA, Vol. 110, Page 20461-, Year 2013
Publish dateJun 24, 2013 (structure data deposition date)
AuthorsLewis, M. / Arnot, C.J. / Beeston, H. / Mccoy, A. / Ashcroft, A.E. / Gay, N.J. / Gangloff, M.
External linksProc. Natl. Acad. Sci. USA / PubMed:24282309
MethodsX-ray diffraction
Resolution2.35 Å
Structure data

PDB-4bv4:
Structure and allostery in Toll-Spatzle recognition
Method: X-RAY DIFFRACTION / Resolution: 2.35 Å

Chemicals

ChemComp-NAG:
2-acetamido-2-deoxy-beta-D-glucopyranose

ChemComp-HOH:
WATER

Source
  • drosophila melanogaster (fruit fly)
  • eptatretus burgeri (inshore hagfish)
KeywordsIMMUNE SYSTEM / CYTOKINE RECOGNITION / EMBRYONIC DEVELOPMENT / INNATE IMMUNITY / LEUCINE-RICH REPEATS / CYSTINE-KNOT / GLYCOPROTEIN

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