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-Structure paper
タイトル | Design, synthesis, and biological evaluation of potent and selective class IIa histone deacetylase (HDAC) inhibitors as a potential therapy for Huntington's disease. |
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ジャーナル・号・ページ | J. Med. Chem., Vol. 56, Page 9934-9954, Year 2013 |
掲載日 | 2013年10月16日 (構造データの登録日) |
![]() | Burli, R.W. / Luckhurst, C.A. / Aziz, O. / Matthews, K.L. / Yates, D. / Lyons, K.A. / Beconi, M. / McAllister, G. / Breccia, P. / Stott, A.J. ...Burli, R.W. / Luckhurst, C.A. / Aziz, O. / Matthews, K.L. / Yates, D. / Lyons, K.A. / Beconi, M. / McAllister, G. / Breccia, P. / Stott, A.J. / Penrose, S.D. / Wall, M. / Lamers, M. / Leonard, P. / Muller, I. / Richardson, C.M. / Jarvis, R. / Stones, L. / Hughes, S. / Wishart, G. / Haughan, A.F. / O'Connell, C. / Mead, T. / McNeil, H. / Vann, J. / Mangette, J. / Maillard, M. / Beaumont, V. / Munoz-Sanjuan, I. / Dominguez, C. |
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手法 | X線回折 |
解像度 | 2.72 - 3.03 Å |
構造データ | ![]() PDB-4cbt: ![]() PDB-4cby: |
化合物 | ![]() ChemComp-9F4: ![]() ChemComp-ZN: ![]() ChemComp-HOH: ![]() ChemComp-KEE: ![]() ChemComp-NA: |
由来 |
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![]() | HYDROLASE / NEURODEGENERATION / HUNTINGTONS DISEASE / AMYOTROPHIC LATERAL SCLEROSIS / MUSCLE ATROPHY / CLASS IIA HISTONE DEACETYLASE INHIBITORS / SAR / HYDROXAMIC ACID / CYCLOPROPANATION |