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TitleLipoamide channel-binding sulfonamides selectively inhibit mycobacterial lipoamide dehydrogenase.
Journal, issue, pagesBiochemistry, Vol. 52, Page 9375-9384, Year 2013
Publish dateAug 7, 2013 (structure data deposition date)
AuthorsBryk, R. / Arango, N. / Maksymiuk, C. / Balakrishnan, A. / Wu, Y.T. / Wong, C.H. / Masquelin, T. / Hipskind, P. / Lima, C.D. / Nathan, C.
External linksBiochemistry / PubMed:24251446
MethodsX-ray diffraction
Resolution2.4 Å
Structure data

PDB-4m52:
Structure of Mtb Lpd bound to SL827
Method: X-RAY DIFFRACTION / Resolution: 2.4 Å

Chemicals

ChemComp-FAD:
FLAVIN-ADENINE DINUCLEOTIDE / FAD*YM

ChemComp-M52:
N~2~-[(2-amino-5-bromopyridin-3-yl)sulfonyl]-N-(4-methoxyphenyl)-N~2~-methylglycinamide

ChemComp-HOH:
WATER

Source
  • mycobacterium tuberculosis (bacteria)
KeywordsOXIDOREDUCTASE / FLAVOPROTEIN / GLYCOLYSIS / REDOX-ACTIVE CENTER

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