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TitleDimerization of LT beta R by LT alpha 1 beta 2 is necessary and sufficient for signal transduction.
Journal, issue, pagesProc. Natl. Acad. Sci. USA, Vol. 110, Page 19896-19901, Year 2013
Publish dateSep 26, 2013 (structure data deposition date)
AuthorsSudhamsu, J. / Yin, J. / Chiang, E.Y. / Starovasnik, M.A. / Grogan, J.L. / Hymowitz, S.G.
External linksProc. Natl. Acad. Sci. USA / PubMed:24248355
MethodsX-ray diffraction
Resolution3.2 - 3.6 Å
Structure data

PDB-4mxv:
Structure of Lymphotoxin alpha bound to anti-LTa Fab
Method: X-RAY DIFFRACTION / Resolution: 3.2 Å

PDB-4mxw:
Structure of heterotrimeric lymphotoxin LTa1b2 bound to lymphotoxin beta receptor LTbR and anti-LTa Fab
Method: X-RAY DIFFRACTION / Resolution: 3.6 Å

Source
  • homo sapiens (human)
KeywordsCYTOKINE/IMMUNE SYSTEM / TNF / Tumor Necrosis Factor / TNFR Receptor / lymphotoxin beta receptor / lymphotoxin alpha / Lymphoid development / Tumor immunity / Auto-immunity / CYTOKINE-IMMUNE SYSTEM complex

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