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Structure paper

TitleDestabilization of the Homotetrameric Assembly of 3-Deoxy-D-Arabino-Heptulosonate 7-Phosphate Synthase from the Hyperthermophile Pyrococcus Furiosus Enhances Enzymatic Activity
Journal, issue, pagesJ. Mol. Biol., Vol. 426, Page 656-, Year 2014
Publish dateAug 13, 2013 (structure data deposition date)
AuthorsNazmi, A.R. / Schofield, L.R. / Dobson, R.C.J. / Jameson, G.B. / Parker, E.J.
External linksJ. Mol. Biol. / PubMed:24239948
MethodsX-ray diffraction
Resolution1.8 - 2.15 Å
Structure data

PDB-4c1k:
Crystal structure of pyrococcus furiosus 3-deoxy-D-arabino- heptulosonate 7-phosphate synthase
Method: X-RAY DIFFRACTION / Resolution: 2.15 Å

PDB-4c1l:
Crystal structure of pyrococcus furiosus 3-deoxy-D-arabino- heptulosonate 7-phosphate synthase I181D interface mutant
Method: X-RAY DIFFRACTION / Resolution: 1.8 Å

Chemicals

ChemComp-CO3:
CARBONATE ION

ChemComp-PEP:
PHOSPHOENOLPYRUVATE

ChemComp-CD:
Unknown entry

ChemComp-CL:
Unknown entry

ChemComp-2PE:
NONAETHYLENE GLYCOL / precipitant*YM

ChemComp-HOH:
WATER

ChemComp-MN:
Unknown entry

ChemComp-K:
Unknown entry

ChemComp-1PE:
PENTAETHYLENE GLYCOL / precipitant*YM

Source
  • pyrococcus furiosus (archaea)
KeywordsTRANSFERASE / SHIKIMATE PATHWAY / INTERFACE MUTANT

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