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-Structure paper
Title | Antidiabetic effects of glucokinase regulatory protein small-molecule disruptors. |
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Journal, issue, pages | Nature, Vol. 504, Page 437-440, Year 2013 |
Publish date | Jul 30, 2013 (structure data deposition date) |
Authors | Lloyd, D.J. / St Jean, D.J. / Kurzeja, R.J. / Wahl, R.C. / Michelsen, K. / Cupples, R. / Chen, M. / Wu, J. / Sivits, G. / Helmering, J. ...Lloyd, D.J. / St Jean, D.J. / Kurzeja, R.J. / Wahl, R.C. / Michelsen, K. / Cupples, R. / Chen, M. / Wu, J. / Sivits, G. / Helmering, J. / Komorowski, R. / Ashton, K.S. / Pennington, L.D. / Fotsch, C. / Vazir, M. / Chen, K. / Chmait, S. / Zhang, J. / Liu, L. / Norman, M.H. / Andrews, K.L. / Bartberger, M.D. / Van, G. / Galbreath, E.J. / Vonderfecht, S.L. / Wang, M. / Jordan, S.R. / Veniant, M.M. / Hale, C. |
External links | Nature / PubMed:24226772 |
Methods | X-ray diffraction |
Resolution | 2.35 Å |
Structure data | PDB-4ly9: |
Chemicals | ChemComp-IOD: ChemComp-S6P: ChemComp-1YY: ChemComp-GOL: ChemComp-SO4: ChemComp-HOH: |
Source |
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Keywords | Carbohydrate Binding protein / Regulatory protein / disruptor ligand complex / SIS domains / GKRP binds to GK / Liver |