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TitleIdentification of a Small Peptide That Inhibits PCSK9 Protein Binding to the Low Density Lipoprotein Receptor.
Journal, issue, pagesJ. Biol. Chem., Vol. 289, Page 942-955, Year 2014
Publish dateNov 15, 2013 (structure data deposition date)
AuthorsZhang, Y. / Eigenbrot, C. / Zhou, L. / Shia, S. / Li, W. / Quan, C. / Tom, J. / Moran, P. / Di Lello, P. / Skelton, N.J. ...Zhang, Y. / Eigenbrot, C. / Zhou, L. / Shia, S. / Li, W. / Quan, C. / Tom, J. / Moran, P. / Di Lello, P. / Skelton, N.J. / Kong-Beltran, M. / Peterson, A. / Kirchhofer, D.
External linksJ. Biol. Chem. / PubMed:24225950
MethodsX-ray diffraction
Resolution1.85 Å
Structure data

PDB-4nmx:
PCSK9(deltaCRD) in complex with phage-derived inhibitory peptide 2-8
Method: X-RAY DIFFRACTION / Resolution: 1.85 Å

Chemicals

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsHYDROLASE/HYDROLASE INHIBITOR / subtlisin / receptor degradation / LDL receptor / HYDROLASE-HYDROLASE INHIBITOR complex

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