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TitleDiscovery and Characterization of a Novel Dihydroisoxazole Class of alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) Receptor Potentiators.
Journal, issue, pagesJ. Med. Chem., Vol. 56, Page 9180-9191, Year 2013
Publish dateJul 31, 2013 (structure data deposition date)
AuthorsPatel, N.C. / Schwarz, J. / Hou, X.J. / Hoover, D.J. / Xie, L. / Fliri, A.J. / Gallaschun, R.J. / Lazzaro, J.T. / Bryce, D.K. / Hoffmann, W.E. ...Patel, N.C. / Schwarz, J. / Hou, X.J. / Hoover, D.J. / Xie, L. / Fliri, A.J. / Gallaschun, R.J. / Lazzaro, J.T. / Bryce, D.K. / Hoffmann, W.E. / Hanks, A.N. / McGinnis, D. / Marr, E.S. / Gazard, J.L. / Hajos, M. / Scialis, R.J. / Hurst, R.S. / Shaffer, C.L. / Pandit, J. / O'Donnell, C.J.
External linksJ. Med. Chem. / PubMed:24215237
MethodsX-ray diffraction
Resolution1.5 - 2.1 Å
Structure data

PDB-4lz5:
Crystal structures of GLuR2 ligand-binding-domain in complex with glutamate and positive allosteric modulators
Method: X-RAY DIFFRACTION / Resolution: 1.5 Å

PDB-4lz7:
Crystal structures of GLuR2 ligand-binding-domain in complex with glutamate and positive allosteric modulators
Method: X-RAY DIFFRACTION / Resolution: 2.1 Å

PDB-4lz8:
Crystal structures of GLuR2 ligand-binding-domain in complex with glutamate and positive allosteric modulators
Method: X-RAY DIFFRACTION / Resolution: 1.85 Å

Chemicals

ChemComp-GLU:
GLUTAMIC ACID

ChemComp-ZN:
Unknown entry

ChemComp-1YV:
N-[(2R)-2-(4'-cyanobiphenyl-4-yl)propyl]propane-2-sulfonamide

ChemComp-HOH:
WATER

ChemComp-1YW:
N-({(5S)-3-[3-fluoro-4-(pyrrolidin-1-yl)phenyl]-4,5-dihydro-1,2-oxazol-5-yl}methyl)acetamide

ChemComp-1YX:
N-[(3S)-1-{2-fluoro-4-[(5S)-5-{[(propan-2-ylsulfonyl)amino]methyl}-4,5-dihydro-1,2-oxazol-3-yl]phenyl}pyrrolidin-3-yl]acetamide

Source
  • rattus norvegicus (Norway rat)
KeywordsTRANSPORT PROTEIN / AMPA receptor / allosteric modulator

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