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TitleInhibitory mechanism of an allosteric antibody targeting the glucagon receptor.
Journal, issue, pagesJ. Biol. Chem., Vol. 288, Page 36168-36178, Year 2013
Publish dateJun 26, 2013 (structure data deposition date)
AuthorsMukund, S. / Shang, Y. / Clarke, H.J. / Madjidi, A. / Corn, J.E. / Kates, L. / Kolumam, G. / Chiang, V. / Luis, E. / Murray, J. ...Mukund, S. / Shang, Y. / Clarke, H.J. / Madjidi, A. / Corn, J.E. / Kates, L. / Kolumam, G. / Chiang, V. / Luis, E. / Murray, J. / Zhang, Y. / Hotzel, I. / Koth, C.M. / Allan, B.B.
External linksJ. Biol. Chem. / PubMed:24189067
MethodsX-ray diffraction
Resolution2.02 - 2.735 Å
Structure data

PDB-4lex:
Unliganded crystal structure of mAb7
Method: X-RAY DIFFRACTION / Resolution: 2.02 Å

PDB-4lf3:
Inhibitory Mechanism of an Allosteric Antibody Targeting the Glucagon Receptor
Method: X-RAY DIFFRACTION / Resolution: 2.735 Å

Chemicals

ChemComp-HOH:
WATER

Source
  • mus musculus (house mouse)
  • homo sapiens (human)
KeywordsIMMUNE SYSTEM / Fab fragment / anti-GCGR / Fab heavy and light chain / Antibody / GCGR

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