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Title | 5-Chlorothiophene-2-Carboxylic Acid [(S)-2-[2-Methyl-3-(2-Oxopyrrolidin-1-Yl)Benzenesulfonylamino]-3-(4-Methylpiperazin-1-Yl)-3-Oxopropyl]Amide (Sar107375), a Selective and Potent Orally Active Dual Thrombin and Factor Xa Inhibitor. |
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Journal, issue, pages | J. Med. Chem., Vol. 56, Page 9441-, Year 2013 |
Publish date | Jun 18, 2013 (structure data deposition date) |
![]() | Meneyrol, J. / Follmann, M. / Lassalle, G. / Wehner, V. / Barre, G. / Rousseaux, T. / Altenburger, J. / Petit, F. / Bocskei, Z. / Schreuder, H. ...Meneyrol, J. / Follmann, M. / Lassalle, G. / Wehner, V. / Barre, G. / Rousseaux, T. / Altenburger, J. / Petit, F. / Bocskei, Z. / Schreuder, H. / Alet, N. / Herault, J. / Millet, L. / Dol, F. / Florian, P. / Schaeffer, P. / Sadoun, F. / Klieber, S. / Briot, C. / Bono, F. / Herbert, J. |
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Methods | X-ray diffraction |
Resolution | 1.61 - 2.59 Å |
Structure data | ![]() PDB-4bti: ![]() PDB-4btt: ![]() PDB-4btu: ![]() PDB-4loy: ![]() PDB-4lxb: |
Chemicals | ![]() ChemComp-CA: ![]() ChemComp-7R9: ![]() ChemComp-HOH: ![]() ChemComp-VYR: ![]() ChemComp-6XS: ![]() ChemComp-NAG: ![]() ChemComp-NA: |
Source |
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![]() | HYDROLASE / SAR107375 / FACTOR XA INHIBITOR / THROMBIN INHIBITOR / CHLOROTHIOPHENE P1 FRAGMENT / S3 SUBSITE / MICROSOMES STABILITY / ORAL ANTITHROMBOTIC / DUAL INHIBITOR / IV ANTITHROMBOTIC / hydrolase/hydrolase inhibitor / serine proteases / dual thrombin/factor Xa inhibition / hydrolase-hydrolase inhibitor complex / antithrombotic agents / dual thrombin/factor Xa inhi |