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Structure paper

TitleCrossreactivity of a human autoimmune TCR is dominated by a single TCR loop.
Journal, issue, pagesNat Commun, Vol. 4, Page 2623-2623, Year 2013
Publish dateAug 25, 2012 (structure data deposition date)
AuthorsSethi, D.K. / Gordo, S. / Schubert, D.A. / Wucherpfennig, K.W.
External linksNat Commun / PubMed:24136005
MethodsX-ray diffraction
Resolution2.2 - 2.86 Å
Structure data

PDB-4grl:
Crystal structure of a autoimmune TCR-MHC complex
Method: X-RAY DIFFRACTION / Resolution: 2.86 Å

PDB-4may:
Crystal structure of an immune complex
Method: X-RAY DIFFRACTION / Resolution: 2.2 Å

Chemicals

ChemComp-NAG:
2-acetamido-2-deoxy-beta-D-glucopyranose

ChemComp-HOH:
WATER

ChemComp-SO4:
SULFATE ION

Source
  • homo sapiens (human)
  • unidentified herpesvirus
KeywordsIMMUNE SYSTEM / immune complex / peptide antigen presentation / multiple sclerosis / autoimmunity / antigen presentation

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